UFC on ESPN 40: Santos vs. Hill was a mixed martial arts event produced by the Ultimate Fighting Championship that took place on August 6, 2022, at the UFC Apex facility in Enterprise, Nevada, part of the Las Vegas Metropolitan Area, United States. A light heavyweight bout between former UFC Light Heavyweight title challenger Thiago Santos and Jamahal Hill headlined the event. The heavyweight and women's flyweight finals of The Ultimate Fighter: Team Peña vs. Team Nunes took place at the event.

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