UFC 321: Aspinall vs. Gane was a mixed martial arts event produced by the Ultimate Fighting Championship that took place on October 25, 2025, at the Etihad Arena in Abu Dhabi, United Arab Emirates. A UFC Heavyweight Championship bout between current champion Tom Aspinall and former interim champion Ciryl Gane headlined the event. A UFC Women's Strawweight Championship bout for the vacant title between former Invicta FC Strawweight Champion Virna Jandiroba and Mackenzie Dern took place in the co-main event.

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