UFC on ESPN 29: Cannonier vs. Gastelum was a mixed martial arts event produced by the Ultimate Fighting Championship that took place on August 21, 2021, at the UFC Apex facility in Enterprise, Nevada, part of the Las Vegas Metropolitan Area, United States. A middleweight bout between Jared Cannonier and former interim title challenger and The Ultimate Fighter: Team Jones vs. Team Sonnen middleweight winner Kelvin Gastelum headlined this event.

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