UFC 263: Adesanya vs. Vettori 2 was a mixed martial arts event produced by the Ultimate Fighting Championship that took place on June 12, 2021, at the Gila River Arena in Glendale, Arizona, United States. A UFC Middleweight Championship bout between then champion Israel Adesanya and Marvin Vettori headlined the event. The pair previously met at UFC on Fox: Poirier vs. Gaethje, where Adesanya won via split decision.

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